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Table 6 Titration Schedule for Basal and Prandial Insulin [6]

From: A practical approach for implementation of a basal-prandial insulin therapy regimen in patients with type 2 diabetes

Blood Glucose Levels for 3 Consecutive Days (Fasting, Preprandial, or Bedtime) Adjust Basal Insulin Dose (U)* Adjust Rapid-Acting Insulin Dose (U per Injection)
180 mg/dL +8 +3
160–180 mg/dL +6 +2
140–160 mg/dL +4 +2
120–140 mg/dL +2 +1
100–120 mg/dL +1 Maintain dose
80–100 mg/dL Maintain dose - 1
60–80 mg/dL - 2 - 2
< 60 mg/dL - 4 - 4
Comments: • For elevated fasting blood glucose levels, adjust only the basal insulin dose • For elevated preprandial blood glucose at lunchtime, adjust breakfast rapid-acting insulin dose
• For elevated preprandial blood glucose at dinnertime, adjust lunchtime rapid-acting insulin dose
• For elevated bedtime blood glucose, adjust dinnertime rapid-acting insulin dose
  1. *Copyright © 2003 American Diabetes Association from Diabetes Care, Vol. 26, 2003; 3080–3086. Modified with permission from The American Diabetes Association.
  2. If any single blood glucose measurement is in this range, make the appropriate reduction in insulin dose.