Analysis of adverse events comparing treatment groups. OMT = osteopathic manipulative treatment, LT = light-touch treatment, CCO = conventional care only. Subjects may be included in more than one category. For example, three subjects had respiratory failure as their treatment endpoint and subsequently died while still in the hospital. * Serious adverse event category excludes respiratory failure and death. A, Intention-to-treat analysis. † OMT significantly greater than LT and CCO, P < 0.05. B, Per-protocol analysis. ‡ OMT significantly less than CCO, P < 0.05.