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Table 2 Comparison of Treatment Groups on Primary and Secondary MOPSE Outcomes

From: Efficacy of osteopathic manipulation as an adjunctive treatment for hospitalized patients with pneumonia: a randomized controlled trial

Primary Outcomes

    
 

OMT

LT

CCO

p valuea

Hospital Length of Stay (days)

ITT Analysis

(n = 130)

(n = 124)

(n = 133)

 

   mean (SD)

4.5 (2.7)

4.9 (2.7)

4.5 (2.6)

 

   median (95% CI)

3.9 (3.4-4.7)

4.5 (3.8-4.9)

4.3 (3.9-4.9)

0.53

PP Analysis

(n = 96)

(n = 95)

(n = 127)

 

   mean (SD)

4.0 (2.0)

4.4 (2.4)

4.5 (2.6)

 

   median (95% CI)

3.5 (3.2-4.0)

3.9 (3.5-4.8)

4.5 (3.9-4.9)

0.01 (OMT<CCO)

Time to Clinical Stability (days)

ITT Analysis

(n = 121)

(n = 118)

(n = 130)

 

   mean (SD)

2.5 (1.6)

2.5 (1.4)

2.6 (1.6)

 

   median (95% CI)

2.0 (2.0-2.0)

2.0 (2.0-3.0)

2.0 (2.0-2.0)

0.97

PP Analysis

(n = 90)

(n = 90)

(n = 124)

 

   mean (SD)

2.3 (1.4)

2.5 (1.5)

2.6 (1.6)

 

   median (95% CI)

2.0 (2.0-2.0)

2.0 (2.0-2.0)

2.0 (2.0-2.0)

0.47

Symptomatic and Functional RecoveryScore

ITT Analysis - mean (SD)

(n = 99)

(n = 102)

(n = 99)

 

   - Admission

11.9 (4.6)

11.6 (4.4)

10.6 (4.6)

 

   - 14-day

5.8 (4.5)

5.0 (4.0)

4.4 (3.7)

Interaction (GroupxTime)

   - 30-day

4.1 (4.4)

4.2 (3.6)

4.4 (3.7)

p = 0.24

   - 60-day

4.0 (4.7)

4.0 (4.1)

3.4 (3.6)

Group p = 0.47

PP Analysis - mean (SD)

(n = 80)

(n = 80)

(n = 91)

 

   - Admission

11.6 (4.5)

11.6 (4.4)

10.5 (4.6)

 

   - 14-day

5.1 (3.9)

4.6 (3.8)

4.1 (3.4)

Interaction (GroupxTime)

   - 30-day

3.8 (4.3)

4.0 (3.8)

4.2 (3.7)

p = 0.24

   - 60-day

3.6 (4.9)

3.9 (4.2)

3.2 (3.6)

Group p = 0.73

Secondary Outcomes

    

Duration of Intravenous Antibiotic Use(days)

ITT Analysis

(n = 130)

(n = 124)

(n = 133)

 

   mean (SD)

3.7 (2.6)

3.9 (2.5)

3.9 (2.5)

 

   median (95% CI)

3.3 (2.9-3.7)

3.7 (2.9-3.9)

3.5 (3.1-3.9)

0.44

PP Analysis

(n = 96)

(n = 95)

(n = 127)

 

   mean (SD)

3.4 (1.9)

3.7 (2.5)

3.9 (2.5)

 

   median (95% CI)

3.0 (2.7-3.5)

3.3 (2.7-3.8)

3.5 (3.2-3.9)

0.05 (OMT<CCO)

Duration of Total (Intravenous+Oral) Antibiotic Use (days)

ITT Analysis

(n = 130)

(n = 124)

(n = 133)

 

   mean (SD)

4.2 (2.7)

4.6 (2.5)

4.5 (2.5)

 

   median (95% CI)

3.6 (3.2-4.3)

4.1 (3.7-4.8)

4.0 (3.6-4.8)

0.43

PP Analysis

(n = 96)

(n = 95)

(n = 127)

 

   mean (SD)

4.0 (2.0)

4.4 (2.4)

4.5 (2.5)

 

   median (95% CI)

3.5 (3.0-3.9)

3.7 (3.1-4.6)

4.0 (3.6-4.8)

0.08

Treatment Endpoint

ITT Analysis

(n = 124)

(n = 124)

(n = 132)

 

   n (%) Death

2 (2)

3 (3)

8 (6)

0.08

   n (%) Respiratory Failure

4 (3)

4 (3)

10 (8)

 

   n (%) Discharge

118 (95)

117 (94)

114 (86)

 

PP Analysis

(n = 96)

(n = 95)

(n = 127)

 

   n (%) Death

0 (0)

3 (3)

8 (6)

0.006b

   n (%) Respiratory Failure

1 (1)

2 (2)

9 (7)

 

   n (%) Discharge

95 (99)

90 (95)

110 (87)

 

60-day Hospital ReadmissionRate

ITT Analysis

(n = 93)

(n = 96)

(n = 96)

 

   n (%) Readmission

16 (17)

20 (21)

21 (22)

0.64

PP Analysis

(n = 80)

(n = 79)

(n = 92)

 

   n (%) Readmission

9 (11)

16 (20)

19 (21)

0.16

  1. ITT = intention-to-treat, PP = per-protocol, OMT = osteopathic manipulative treatment, LT = light-touch treatment, CCO = conventional care only, CI = confidence interval.
  2. a P values are for overall comparisons across three groups. Results from multiple comparisons are reported in parentheses.
  3. b Death and respiratory failure were less common in the OMT group compared to the CCO group.
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Osteopathic Medicine and Primary Care

ISSN: 1750-4732