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Table 2 Comparison of Treatment Groups on Primary and Secondary MOPSE Outcomes

From: Efficacy of osteopathic manipulation as an adjunctive treatment for hospitalized patients with pneumonia: a randomized controlled trial

Primary Outcomes     
  OMT LT CCO p valuea
Hospital Length of Stay (days)
ITT Analysis (n = 130) (n = 124) (n = 133)  
   mean (SD) 4.5 (2.7) 4.9 (2.7) 4.5 (2.6)  
   median (95% CI) 3.9 (3.4-4.7) 4.5 (3.8-4.9) 4.3 (3.9-4.9) 0.53
PP Analysis (n = 96) (n = 95) (n = 127)  
   mean (SD) 4.0 (2.0) 4.4 (2.4) 4.5 (2.6)  
   median (95% CI) 3.5 (3.2-4.0) 3.9 (3.5-4.8) 4.5 (3.9-4.9) 0.01 (OMT<CCO)
Time to Clinical Stability (days)
ITT Analysis (n = 121) (n = 118) (n = 130)  
   mean (SD) 2.5 (1.6) 2.5 (1.4) 2.6 (1.6)  
   median (95% CI) 2.0 (2.0-2.0) 2.0 (2.0-3.0) 2.0 (2.0-2.0) 0.97
PP Analysis (n = 90) (n = 90) (n = 124)  
   mean (SD) 2.3 (1.4) 2.5 (1.5) 2.6 (1.6)  
   median (95% CI) 2.0 (2.0-2.0) 2.0 (2.0-2.0) 2.0 (2.0-2.0) 0.47
Symptomatic and Functional RecoveryScore
ITT Analysis - mean (SD) (n = 99) (n = 102) (n = 99)  
   - Admission 11.9 (4.6) 11.6 (4.4) 10.6 (4.6)  
   - 14-day 5.8 (4.5) 5.0 (4.0) 4.4 (3.7) Interaction (GroupxTime)
   - 30-day 4.1 (4.4) 4.2 (3.6) 4.4 (3.7) p = 0.24
   - 60-day 4.0 (4.7) 4.0 (4.1) 3.4 (3.6) Group p = 0.47
PP Analysis - mean (SD) (n = 80) (n = 80) (n = 91)  
   - Admission 11.6 (4.5) 11.6 (4.4) 10.5 (4.6)  
   - 14-day 5.1 (3.9) 4.6 (3.8) 4.1 (3.4) Interaction (GroupxTime)
   - 30-day 3.8 (4.3) 4.0 (3.8) 4.2 (3.7) p = 0.24
   - 60-day 3.6 (4.9) 3.9 (4.2) 3.2 (3.6) Group p = 0.73
Secondary Outcomes     
Duration of Intravenous Antibiotic Use(days)
ITT Analysis (n = 130) (n = 124) (n = 133)  
   mean (SD) 3.7 (2.6) 3.9 (2.5) 3.9 (2.5)  
   median (95% CI) 3.3 (2.9-3.7) 3.7 (2.9-3.9) 3.5 (3.1-3.9) 0.44
PP Analysis (n = 96) (n = 95) (n = 127)  
   mean (SD) 3.4 (1.9) 3.7 (2.5) 3.9 (2.5)  
   median (95% CI) 3.0 (2.7-3.5) 3.3 (2.7-3.8) 3.5 (3.2-3.9) 0.05 (OMT<CCO)
Duration of Total (Intravenous+Oral) Antibiotic Use (days)
ITT Analysis (n = 130) (n = 124) (n = 133)  
   mean (SD) 4.2 (2.7) 4.6 (2.5) 4.5 (2.5)  
   median (95% CI) 3.6 (3.2-4.3) 4.1 (3.7-4.8) 4.0 (3.6-4.8) 0.43
PP Analysis (n = 96) (n = 95) (n = 127)  
   mean (SD) 4.0 (2.0) 4.4 (2.4) 4.5 (2.5)  
   median (95% CI) 3.5 (3.0-3.9) 3.7 (3.1-4.6) 4.0 (3.6-4.8) 0.08
Treatment Endpoint
ITT Analysis (n = 124) (n = 124) (n = 132)  
   n (%) Death 2 (2) 3 (3) 8 (6) 0.08
   n (%) Respiratory Failure 4 (3) 4 (3) 10 (8)  
   n (%) Discharge 118 (95) 117 (94) 114 (86)  
PP Analysis (n = 96) (n = 95) (n = 127)  
   n (%) Death 0 (0) 3 (3) 8 (6) 0.006b
   n (%) Respiratory Failure 1 (1) 2 (2) 9 (7)  
   n (%) Discharge 95 (99) 90 (95) 110 (87)  
60-day Hospital ReadmissionRate
ITT Analysis (n = 93) (n = 96) (n = 96)  
   n (%) Readmission 16 (17) 20 (21) 21 (22) 0.64
PP Analysis (n = 80) (n = 79) (n = 92)  
   n (%) Readmission 9 (11) 16 (20) 19 (21) 0.16
  1. ITT = intention-to-treat, PP = per-protocol, OMT = osteopathic manipulative treatment, LT = light-touch treatment, CCO = conventional care only, CI = confidence interval.
  2. a P values are for overall comparisons across three groups. Results from multiple comparisons are reported in parentheses.
  3. b Death and respiratory failure were less common in the OMT group compared to the CCO group.