Hospital Length of Stay (days)

ITT Analysis

(n = 130)

(n = 124)

(n = 133)
 
mean (SD)

4.5 (2.7)

4.9 (2.7)

4.5 (2.6)
 
median (95% CI)

3.9 (3.44.7)

4.5 (3.84.9)

4.3 (3.94.9)

0.53

PP Analysis

(n = 96)

(n = 95)

(n = 127)
 
mean (SD)

4.0 (2.0)

4.4 (2.4)

4.5 (2.6)
 
median (95% CI)

3.5 (3.24.0)

3.9 (3.54.8)

4.5 (3.94.9)

0.01 (OMT<CCO)

Time to Clinical Stability (days)

ITT Analysis

(n = 121)

(n = 118)

(n = 130)
 
mean (SD)

2.5 (1.6)

2.5 (1.4)

2.6 (1.6)
 
median (95% CI)

2.0 (2.02.0)

2.0 (2.03.0)

2.0 (2.02.0)

0.97

PP Analysis

(n = 90)

(n = 90)

(n = 124)
 
mean (SD)

2.3 (1.4)

2.5 (1.5)

2.6 (1.6)
 
median (95% CI)

2.0 (2.02.0)

2.0 (2.02.0)

2.0 (2.02.0)

0.47

Symptomatic and Functional RecoveryScore

ITT Analysis  mean (SD)

(n = 99)

(n = 102)

(n = 99)
 
 Admission

11.9 (4.6)

11.6 (4.4)

10.6 (4.6)
 
 14day

5.8 (4.5)

5.0 (4.0)

4.4 (3.7)

Interaction (GroupxTime)

 30day

4.1 (4.4)

4.2 (3.6)

4.4 (3.7)

p = 0.24

 60day

4.0 (4.7)

4.0 (4.1)

3.4 (3.6)

Group p = 0.47

PP Analysis  mean (SD)

(n = 80)

(n = 80)

(n = 91)
 
 Admission

11.6 (4.5)

11.6 (4.4)

10.5 (4.6)
 
 14day

5.1 (3.9)

4.6 (3.8)

4.1 (3.4)

Interaction (GroupxTime)

 30day

3.8 (4.3)

4.0 (3.8)

4.2 (3.7)

p = 0.24

 60day

3.6 (4.9)

3.9 (4.2)

3.2 (3.6)

Group p = 0.73

Secondary Outcomes
    
Duration of Intravenous Antibiotic Use(days)

ITT Analysis

(n = 130)

(n = 124)

(n = 133)
 
mean (SD)

3.7 (2.6)

3.9 (2.5)

3.9 (2.5)
 
median (95% CI)

3.3 (2.93.7)

3.7 (2.93.9)

3.5 (3.13.9)

0.44

PP Analysis

(n = 96)

(n = 95)

(n = 127)
 
mean (SD)

3.4 (1.9)

3.7 (2.5)

3.9 (2.5)
 
median (95% CI)

3.0 (2.73.5)

3.3 (2.73.8)

3.5 (3.23.9)

0.05 (OMT<CCO)

Duration of Total (Intravenous+Oral) Antibiotic Use (days)

ITT Analysis

(n = 130)

(n = 124)

(n = 133)
 
mean (SD)

4.2 (2.7)

4.6 (2.5)

4.5 (2.5)
 
median (95% CI)

3.6 (3.24.3)

4.1 (3.74.8)

4.0 (3.64.8)

0.43

PP Analysis

(n = 96)

(n = 95)

(n = 127)
 
mean (SD)

4.0 (2.0)

4.4 (2.4)

4.5 (2.5)
 
median (95% CI)

3.5 (3.03.9)

3.7 (3.14.6)

4.0 (3.64.8)

0.08

Treatment Endpoint

ITT Analysis

(n = 124)

(n = 124)

(n = 132)
 
n (%) Death

2 (2)

3 (3)

8 (6)

0.08

n (%) Respiratory Failure

4 (3)

4 (3)

10 (8)
 
n (%) Discharge

118 (95)

117 (94)

114 (86)
 
PP Analysis

(n = 96)

(n = 95)

(n = 127)
 
n (%) Death

0 (0)

3 (3)

8 (6)

0.006^{b}

n (%) Respiratory Failure

1 (1)

2 (2)

9 (7)
 
n (%) Discharge

95 (99)

90 (95)

110 (87)
 
60day Hospital ReadmissionRate

ITT Analysis

(n = 93)

(n = 96)

(n = 96)
 
n (%) Readmission

16 (17)

20 (21)

21 (22)

0.64

PP Analysis

(n = 80)

(n = 79)

(n = 92)
 
n (%) Readmission

9 (11)

16 (20)

19 (21)

0.16
